Do not use this medication if you are allergic to amoxapine, or if you have recently had a heart attack. Do not use amoxapine if you have used an MAO inhibitor such as:

• isocarboxazid (Marplan®)
• phenelzine (Nardil®)
• rasagiline (Azilect®)
• selegiline (Eldepryl®, Emsam®)
• tranylcypromine (Parnate®)

within the past 14 days.

You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking this medication you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

• mood changes
• anxiety
• panic attacks
• trouble sleeping
• irritability
• agitation
• aggressiveness
• severe restlessness
• mania (mental and/ or physical hyperactivity)
• thoughts of suicide or hurting yourself

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.

It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.

Do not use this medication if you are allergic to amoxapine, or if you have recently had a heart attack. Do not use amoxapine if you have used an MAO inhibitor such as:

• isocarboxazid (Marplan®)
• phenelzine (Nardil®)
• rasagiline (Azilect®)
• selegiline (Eldepryl®, Emsam®)
• tranylcypromine (Parnate®)

within the past 14 days. Serious, life-threatening side effects can occur if you take amoxapine before the MAO inhibitor has cleared from your body. Before taking amoxapine, tell your doctor if you are allergic to any drugs, or if you have:

• heart disease
• history of heart attack, stroke, or seizures
• kidney disease
• schizophrenia or other mental illness
• diabetes (amoxapine may raise or lower blood sugar)
• glaucoma
• problems with urination

If you have any of these conditions, you may not be able to use amoxapine, or you may need a dosage adjustment or special tests during treatment.

You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking amoxapine, you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed.

In addition to you watching for changes in your own symptoms, your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

• mood changes
• anxiety
• panic attacks
• trouble sleeping
• irritability
• agitation
• aggressiveness
• severe restlessness
• mania (mental and/ or physical hyperactivity)
• thoughts of suicide or hurting yourself

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Amoxapine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from this medicine.

Do not give this medication to anyone under 16 years old.

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of amoxapine can be fatal.

Symptoms of an amoxapine overdose may include:

• uneven heartbeats
• increase or decrease in urination
• drowsiness
• agitation
• confusion
• hallucinations
• seizure (convulsions)
• coma

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction:

• hives
• difficulty breathing
• swelling of your face, lips, tongue, or throat

Call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heart rate
• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
• sudden numbness or weakness, especially on one side of the body
• sudden headache, confusion, problems with vision, speech, or balance
• feeling light-headed, fainting
• restless muscle movements in your eyes, tongue, jaw, or neck
• tremors or uncontrollable shaking
• fever with confusion, muscle stiffness, sweating, and fast or uneven heartbeats

Less serious side effects may be more likely to occur, such as:

• nausea, vomiting, stomach pain, constipation, diarrhea
• dry mouth, unpleasant taste
• increased appetite, weight changes
• weakness, lack of coordination
• numbness or tingly feeling
• feeling anxious, restless, dizzy, drowsy, or tired
• sleep problems (insomnia), nightmares
• blurred vision, headache
• low fever
• mild skin rash
• breast swelling (in men or women)
• decreased sex drive, impotence, or difficulty having an orgasm

Side effects other than those listed here may also occur. Talk to your d octor about any side effect that seems unusual or that is especially bothersome.

Before taking amoxapine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks such as:

• citalopram (Celexa®)
• escitalopram (Lexapro®)
• fluoxetine (Prozac®, Sarafem®)
• fluvoxamine (Luvox®)
• paroxetine (Paxil®)

Before taking amoxapine, tell your doctor if you are currently using any of the following drugs:

• cimetidine (Tagamet®)
• flecainide (Tambocor®)
• propafenone (Rhythmol®)
• quinidine (Cardioquin®, Quinidex®, Quinaglute®)

If you are using any of these drugs, you may not be able to use amoxapine, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with amoxapine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.