Drug Database - Celebrex
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Celebrex is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
Celebrex works by reducing hormones that cause inflammation and pain in the body. Celebrex
is used to treat pain or inflammation caused by many conditions such as arthritis,
and menstrual pain. Celebrex is also used in the treatment of hereditary polyps in the
colon. Celebrex is also used in the treatment of FM and CFS/ME.
How To Use This Medicine
Take this medication exactly as it was prescribed for you.
Do not take the medication
in larger amounts, or take it for longer than recommended by your doctor. Follow
the directions on your prescription label.
Take Celebrex with food or milk to lessen stomach upset.
Do not crush, chew, break,
or open an extended-release capsule. Swallow the pill whole. It is specially made to
release medicine slowly in the body. Breaking or opening the pill would cause too much
of the drug to be released at one time.
Shake the oral suspension (liquid) well just before you measure a dose. To be sure you
get the correct dose, measure the liquid with a marked measuring spoon or medicine cup,
not with a regular table spoon. If you do not have a dose-measuring device, ask
your pharmacist for one.
If you take Celebrex for a long period of time, your doctor may want to check you on a
regular basis to make sure this medication is not causing harmful effects. Do not miss
any scheduled visits to your doctor.
This medication can cause you to have unusual results with certain medical tests.
Tell any doctor who treats you that you are using Celebrex. Store Celebrex at
room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.
Discuss With Your Doctor
Taking an NSAID can increase your risk of life-threatening heart or circulation
problems, including heart attack or stroke. This risk will increase the longer
you use an NSAID. Do not use this medicine just before or after having heart bypass
surgery (also called coronary artery bypass graft, or CABG).
NSAIDs can also increase your risk of serious effects on the stomach or
intestines, including bleeding or perforation (forming of a hole). These conditions
can be fatal and gastrointestinal effects can occur without warning at any time while
you are taking an NSAID. Older adults may have an even greater risk of these
serious gastrointestinal side effects.
Do not use this medication if you are allergic to Celebrex, or if you have a history
of allergic reaction to aspirin or other NSAIDs. Before taking Celebrex tell your doctor
if you are allergic to any drugs, or if you have:
- History of Heart Attack, Stroke, or Blood Clot
- Heart Disease, Congestive Heart Failure, High Blood Pressure
- History of Stomach Ulcers or Bleeding
- Seizure Disorder Such As Epilepsy
- Polyps In Your Nose
- Bleeding or Blood Clotting Disorder
- Kidney Disease
- Liver Disease
If you have any of these conditions, you may not be able to use Celebrex, or you may
need a dosage adjustment or special tests during treatment
This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant
or plan to become pregnant during treatment. Taking Celebrex during the last 3 months
of pregnancy may result in birth defects. Do not take Celebrex during pregnancy unless
your doctor has told you to. Celebrex passes into breast milk and may affect a nursing
baby. Do not take Celebrex without first talking to your doctor if you are breast-feeding
a baby. Do not give this medicine to a child younger than 2 years old without the advice
of a doctor.
If You Miss A Dose
If you are taking Celebrex on a regular schedule, take the missed dose as soon as
you remember. However, if it is almost time for the next dose, skip the missed dose
and take only the next regularly scheduled dose.
Do not take a double dose.
In Case of Overdose
Seek emergency medical attention if you think you have used too much of this
medicine. Symptoms of an Celebrex overdose may include:
- stomach pain
- black or bloody stools
- coughing up blood
- shallow breathing
What To Avoid
Do not drink alcohol while taking Celebrex. Alcohol can increase the risk of
stomach bleeding caused by Celebrex.
Do not use any other over-the-counter cold, allergy, or pain medication without
first asking your doctor or pharmacist. Many medicines available over the counter
contain aspirin or other medicines similar to Celebrex such as:
If you take certain products together you may accidentally take too much of this
type of medication. Read the label of any other medicine you are using to see if it
contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Celebrex
can make your skin more sensitive to sunlight and sunburn may result. Use a
sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
Get emergency medical help if you have any of these signs of an allergic reaction:
- difficulty breathing
- swelling of your face, lips, tongue, or throat
Stop taking Celebrex and seek medical attention or call your doctor at once if you have
any of these serious side effects:
- Chest pain, weakness, shortness of breath, slurred speech
- problems with vision or balance
- Black, bloody, or tarry stools
- Coughing up blood or vomit that looks like coffee grounds
- Swelling or rapid weight gain
- Urinating less than usual or not at all
- Nausea, stomach pain, low fever, loss of appetite
- dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
- Fever, sore throat, and headache with a severe blistering, peeling, and red
- Bruising, severe tingling, numbness, pain, muscle weakness
Less serious side effects may be more likely to occur, such as:
- Upset Stomach, Mild Heartburn, Diarrhea, Constipation
- Bloating, Gas
- Dizziness, Nervousness, Headache
- Skin Rash, Itching
- Blurred Vision
- Ringing In Your Ears
Side effects other than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially bothersome.
Before taking Celebrex, tell your doctor if you are taking any of the following drugs:
- diclofenac (Voltaren®)
- etodolac (Lodine®)
- flurbiprofen (Ansaid®)
- ibuprofen (Advil®, Motrin®)
- ketoprofen (Orudis®)
- ketorolac (Toradol®)
- mefenamic acid (Ponstel®)
- meloxicam (Mobic®)
- nabumetone (Relafen®)
- naproxen (Aleve®, Naprosyn®)
- piroxicam (Feldene®)
- warfarin (Coumadin®)
- furosemide (Lasix®)
- Lithium (Eskalith®, Lithobid®)
- Methotrexate (Rheumatrex®, Trexall®)
- benazepril (Lotensin®)
- captopril (Capoten®)
- fosinopril (Monopril®)
- enalapril (Vasotec®)
- lisinopril (Prinivil®, Zestril®)
- moexipril (Univasc®)
- perindopril (Aceon®)
- quinapril (Accupril®)
- ramipril (Altace®)
- trandolapril (Mavik®)
If you are using any of these drugs, you may not be able to use Celebrex or you may
need dosage adjustments or special tests during treatment.
There may be other drugs not listed that can affect Celebrex. Tell your doctor about
all the prescription and over-the-counter medications you use. This includes
vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start
using a new medication without telling your doctor.
FDA Alert: 4/7/2005:
Celebrex® has been associated with an increased risk of serious adverse
cardiovascular events in a long-term placebo controlled trial. Based on the
currently available data, FDA has concluded that an increased risk of serious
adverse cardiovascular events appears to be a class effect of non-steroidal
anti-inflammatory drugs (NSAIDs) (excluding aspirin).
FDA has requested that the
package insert for all NSAIDs, including Celebrex, be revised to include a boxed
warning to highlight the potential increased risk of cardiovascular events and the
well described risk of serious, and potentially life-threatening, gastrointestinal
FDA has also requested that the package insert for all NSAIDs be revised
to include a contraindication for use in patients immediately post-operative from
coronary artery bypass surgery.