FM/CFS/ME RESOURCES - Drug Database - Doxepin

 

Search Site 
DATABASE INFO
Disability Attornies
Find A Doctor
Drugs Used In FM & CFS/ME
In-Person Support Groups

INFORMATION
Abbreviations
Archived Poll Results
Candles of Hope
CMP Info.
Family and Friends
Financial Help
FM/CFS/ME Facts
Letter To Loved Ones
Living With FM & CFS/ME
Newly Diagnosed
Rate Your Meds  -  Results
Recommend Doctor
Researchers Spotlight

QUIZ & SURVEY
Take Quiz
Quiz Winners
Patient Surveys

Drug Database - Doxepin Doxepin 10 mg. capsule

Generic Name: doxepin (DOX-e-pin)

Brand Names: Adapin®, Sinequan®

Classification: Tricyclic Antidepressant

Issue Date: 1986

Doxepin is in a group of drugs called tricyclic antidepressants. Doxepin affects chemicals in the brain that may become unbalanced. Doxepin is used to treat symptoms of depression and/ or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

  • Before Using This Medicine
  • How To Use This Medicine
  • Precautions While on this Medicine
  • Side Effects
  • Overdosage
  • Drug Interactions
  • Divider
    Before Using This Medicine

    Do not use this medication if you are allergic to doxepin, or if you have glaucoma or problems with urination. Or if you have used an MAO inhibitor such as:

    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    within the past 14 days.

    You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking this medication you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

    Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/or physical hyperactivity)
    • thoughts of suicide or hurting yourself

    Return to top of page

    How To Use This Medicine

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.

    Measure doxepin oral concentrate (liquid) with the special dose-measuring dropper provided. Do not use a regular table spoon. If you do not have a dose-measuring dropper, ask your pharmacist for one.

    Empty the measured dose from the medicine dropper into a small glass (4 ounces) of water, milk, orange juice, tomato juice, prune juice, or pineapple juice. Do not use a carbonated soft drink to mix doxepin oral concentrate. Stir the mixture and drink all of it right away. Do not save it for later use.

    It may take a few weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment.

    Store doxepin at room temperature away from moisture and heat.

    Return to top of page

    Precautions While on this Medicine

    Do not use this medication if you are allergic to doxepin, or if you have glaucoma or problems with urination or if you have used an MAO inhibitor such as:

    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    within the past 14 days. Serious, life-threatening side effects can occur if you take doxepin before the MAO inhibitor has cleared from your body.

    Before taking doxepin, tell your doctor if you are allergic to any drugs, or if you have:

    • bipolar disorder (manic-depression)
    • diabetes (doxepin may raise or lower blood sugar)

    If you have any of these conditions, you may not be able to use doxepin, or you may need a dosage adjustment or special tests during treatment.

    You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. While you are taking doxepin, you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed.

    In addition to you watching for changes in your own symptoms, your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

    Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/ or physical hyperactivity)
    • thoughts of suicide or hurting yourself

    This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether doxepin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Do not give this medication to anyone under 12 years old.

    Return to top of page

    Overdosage

    Seek emergency medical attention if you think you have used too much of this medicine. An overdose of doxepin can be fatal.

    Symptoms of a desipramine overdose include:

    • extreme drowsiness
    • vomiting
    • blurred vision
    • confusion
    • hallucinations
    • muscle stiffness
    • feeling hot or cold
    • seizure (convulsions)
    • coma

    Return to top of page

    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • hives
    • difficulty breathing
    • swelling of your face, lips, tongue, or throat

    Call your doctor at once if you have any of these SERIOUS side effects:

    • fast, pounding, or uneven heart rate
    • chest pain or heavy feeling
    • pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
    • sudden numbness or weakness, especially on one side of the body
    • sudden headache, confusion, problems with vision, speech, or balance
    • confusion, hallucinations, or seizure (convulsions)
    • easy bruising or bleeding, unusual weakness
    • feeling light-headed, fainting
    • tremors, restless muscle movements in your eyes, tongue, jaw, or neck
    • fever with confusion, muscle stiffness, sweating, and fast or uneven heartbeats
    • urinating more or less than usual
    • extreme thirst with headache, nausea, vomiting, and weakness
    • skin rash, bruising, severe tingling, numbness, pain, and muscle weakness
    • nausea, stomach pain, low fever, loss of appetite
    • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

    Less serious side effects may be more likely to occur, such as:

    • vomiting, constipation
    • dry mouth, unpleasant taste
    • weakness, lack of coordination
    • feeling anxious, restless, dizzy, or drowsy
    • sleep problems (insomnia), nightmares
    • blurred vision, trouble concentrating, headache, ringing in your ears
    • breast swelling (in men or women)
    • decreased sex drive, impotence, or difficulty having an orgasm
    • drowsiness, tiredness
    • amnesia or forgetfulness
    • dizziness
    • blurred vision
    • feeling nervous or irritable
    • sleep problems (insomnia)
    • muscle weakness, lack of balance or coordination
    • skin rash
    • dry mouth
    • headache

    Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

    Return to top of page

    Drug Interactions

    Before taking desipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as:

    • citalopram (Celexa®)
    • escitalopram (Lexapro®)
    • fluoxetine (Prozac®, Sarafem®)
    • fluvoxamine (Luvox®)
    • paroxetine (Paxil®)
    • sertraline (Zoloft®)

    Before taking desipramine, tell your doctor if you are currently using any of the following drugs:

    • cimetidine (Tagamet®)
    • guanethidine (Ismelin®)
    • flecainide (Tambocor®)
    • propafenone (Rhythmol®)
    • quinidine (Cardioquin®, Quinidex®, Quinaglute®)

    If you are using any of these drugs, you may not be able to use desipramine, or you may need dosage adjustments or special tests during treatment.

    There are many other medicines that can interact with doxepin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

    Return to Top