Generic Name: selegiline (se-LE-ji-leen)

Brand Names: Eldepryl®

Classification: Monoamine Oxidase Inhibitor (MOAI)

Issue Date: 1993

Eldepryl prevents the breakdown of a chemical in your brain called dopamine (DO-pa-meen). Low levels of this chemical are associated with Parkinson's disease. Eldepryl is used together with other medicines to treat symptoms of Parkinson's disease and Fibromyalgia.

There are many other medicines that can cause serious medical problems if you take them together with Eldepryl. Tell your doctor about all other prescription and over-the-counter medications you use, including vitamins, minerals, and herbal products.

While taking Eldepryl, do not drink alcohol or eat foods that are high in tyramine. Eating tyramine while you are using Eldepryl can raise your blood pressure to dangerous levels and cause life-threatening symptoms.

You should become very familiar with the list of foods to avoid while you are using Eldepryl.

Do not stop taking Eldepryl suddenly or you may have harmful side effects. Keep taking the medicine as prescribed. Talk with your doctor before stopping the medication.

Take Eldepryl exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Larger doses will not have any greater effect, but serious side effects could result. Follow the directions on your prescription label.

Foods that you MAY eat include:

• lunch meat
• hot dogs
• breakfast sausage
• cooked sliced ham
• any vegetables except broad bean pods (fava beans)
• processed cheese
• mozzarella
• ricotta
• cottage cheese
• pizza made with cheeses low in tyramine
• soy milk, yogurt
• brewer's or baker's yeast

You MUST NOT eat foods that are high in tyramine, including::

• air dried meats, aged or fermented meats including:
• sausage or salami
• cacciatore
• mortadella
• pickled herring
• spoiled or improperly stored beef, poultry, fish, or liver
• beer from a tap
• beer that has not been pasteurized
• aged cheeses, including:
• blue
• boursault
• brick
• brie
• camembert
• cheddar
• emmenthaler
• gruyere
• parmesan
• romano
• roquefort
• stilton
• swiss
• over-the-counter supplements or cough and cold medicines that contain tyramine
• sauerkraut
• soy beans
• soy sauce
• tofu
• miso soup
• bean curd
• fava beans
• yeast extracts (such as Marmite)

Eldepryl capsules are usually taken twice a day, at breakfast and lunch. Follow your doctor's instructions.

The disintegrating tablet form of Eldepryl (Zelapar®) should be taken once a day before breakfast and without any liquid.

Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves.

Do not drink or eat anything for at least 5 minutes after taking a Zelapar orally disintegrating tablet.

Parkinson's disease is often treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. When you start taking Eldepryl, your doses of the other medications may need to change. Do not change your doses or medication schedule without advice from your doctor.

Do not stop taking Eldepryl suddenly or you may have harmful side effects. For best results, keep taking the medicine as prescribed.

Do not use this medication if you are allergic to Eldepryl, or if you have used any of the following drugs within the past 14 days:

• cough or cold medicine that contains dextromethorphan
• meperidine (Demerol®)
• propoxyphene (Darvon®, Darvocet®)
• tramadol (Ultram®, Ultracet®)
• methadone (Dolophine®, Methadose®)
• isocarboxazid (Marplan®)
• tranylcypromine (Parnate®)
• phenelzine (Nardi®l)
• rasagiline (Azilect®)
• transdermal Eldepryl (Emsam®)

After you stop taking Eldepryl, you must wait at least 14 days before taking any of the medications listed above.

Before using this medicine, tell your doctor if you have:

• kidney disease
• liver disease
• heart disease
• high or low blood pressure
• a seizure disorder

If you have any of these conditions, you may not be able to use Eldepryl, or you may need a dosage adjustment or special tests during treatment.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Eldepryl passes into breast milk or if it could harm a nursing baby. Do not take Eldepryl without telling your doctor if you are breast-feeding a baby.

The Eldepryl disintegrating tablets may contain phenylalanine. Talk to your doctor before using this form of Eldepryl if you have phenylketonuria (PKU).

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction:

• skin rash or hives
• difficulty breathing
• swelling of your face, lips, tongue, or throat

Stop taking Eldepryl and call your doctor at once if you have any of these SERIOUS side effects:

• sudden and severe headache
• confusion
• blurred vision
• problems with speech or balance
• nausea
• vomiting
• chest pain
• seizure (convulsions)
• sudden numbness or weakness (especially on one side of the body)
• feeling light-headed, fainting
• hallucinations
• feeling restless, agitated, or irritable
• twitching muscle movements
• painful or difficult urination

Continue taking Eldepryl and talk with your doctor if you have any of these less serious side effects:

• dizziness, weakness
• sleep problems (insomnia)
• runny or stuffy nose
• back pain
• constipation
• mouth sores or ulcers, pain with swallowing

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Before taking Eldepryl, tell your doctor if you are using any of the following drugs:

• carbamazepine (Tegretol)
• diet pills or cold medicines that contain:
• ephedrine
• pseudoephedrine
• phenylephrine
• nafcillin (Unipen®)
• phenobarbital (Luminal®, Solfoton®)
• rifampin (Rifadin®, Rifater®, Rifamate®, Rimactane®)
• amitriptyline (Elavil®)
• amoxapine (Ascendin®)
• bupropion (Wellbutrin®, Zyban®)
• citalopram (Celexa®)
• clomipramine (Anafranil®)
• desipramine (Norpramin®)
• doxepin (Sinequan®)
• duloxetine (Cymbalta®)
• escitalopram (Lexapro®)
• fluoxetine (Prozac®)
• fluvoxamine (Luvox®)
• imipramine (Tofranil®)
• nortriptyline (Pamelor®)
• paroxetine (Paxil®)
• protriptyline (Vivactil®)
• sertraline (Zoloft®)
• venlafaxine (Effexor®)
• trimipramine (Surmontil®)

If you are using any of these drugs, you may not be able to take Eldepryl, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can cause serious medical problems if you take them together with Eldepryl. Do not take Eldepryl before telling your doctor about all other prescription and over-the-counter medications you use. This includes:

• vitamins
• minerals
• herbal products
• drugs prescribed by other doctors

Keep a list with you of all the medicines you use and show this list to any doctor, dentist, or other healthcare provider who treats you.