FM/CFS/ME RESOURCES - Drug Database - Flexeril


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Drug Database - Flexeril Flexeril 10 mg. tablet

Generic Name: cyclobenzaprine

Brand Names: Flexeril®

Classification: Muscle Relaxant

Issue Date: 1984

Flexeril is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is used to treat pain, tenderness, and limited motion caused by muscle spasms. This medication is used together with rest and physical therapy for short-term treatment (2 to 3 weeks). Flexeril may also be used for purposes other than those listed here.

  • How To Use This Medicine
  • Discuss With Your Doctor
  • If You Miss A Dose
  • In Case of Overdose
  • What To Avoid
  • Side Effects
  • Drug Interactions
  • Divider
    How To Use This Medicine

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

    Take each dose with a full glass of water. This medication is usually taken three times each day for a period of 2 to 3 weeks. Do not use Flexeril for longer than 3 weeks unless your doctor has told you to.

    Do not stop taking Flexeril suddenly if you have been taking it for longer than 1 week. Stopping suddenly may cause nausea, headache and general discomfort.

    This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Flexeril. Store Flexeril at room temperature away from moisture and heat.

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    Discuss With Your Doctor

    Do not take Flexeril if you have used an MAO inhibitor such as:

    • isocarboxazid (Marplan®)
    • tranylcypromine (Parnate®)
    • phenelzine (Nardil®)
    • selegiline (Eldepryl®, Emsam®)

    within the past 14 days. Serious, life-threatening side effects can occur if you take Flexeril before the MAO inhibitor has cleared from your body.

    Do not use Flexeril if you have recently had a heart attack, or if you have:

    • Heart Rhythm Disorder
    • Congestive Heart Failure
    • Heart Block
    • Overactive Thyroid

    Before using this medication, tell your doctor if you have:

    • Problems with Urination
    • Enlarged Prostate
    • Glaucoma
    • Liver Disease

    If you have any of these conditions, you may not be able to use Flexeril, or you may need a dosage adjustment or special tests during treatment.

    This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

    It is not known whether Flexeril passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Do not give this medication to a child younger than 12 years old. Older adults may be more sensitive to the side effects of this medication.

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    If You Miss A Dose

    Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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    In Case of Overdose

    Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Flexeril can be fatal.

    Symptoms of a Flexeril overdose may include:

    • drowsiness
    • fast heartbeat
    • tremors or shaking
    • slurred speech
    • confusion
    • nausea
    • vomiting
    • hallucinations (seeing things)
    • chest pain
    • seizure (convulsions)

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    What To Avoid

    Flexeril can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid using other medicines that make you sleepy such as:

    • cold medicine
    • pain medication
    • muscle relaxers
    • medicine for seizures, depression or anxiety

    They can add to sleepiness caused by Flexeril. Avoid drinking alcohol, which can increase some of the side effects of Flexeril.

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    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • hives
    • difficulty breathing
    • swelling of your face, lips, tongue, or throat

    Stop using Flexeril and call your doctor at once if you have any of these SERIOUS side effects:

    • Fast, Pounding, or Uneven Heartbeats
    • Chest Pain or Heavy Feeling
    • Pain Spreading to the Arm or Shoulder, Nausea, Sweating
    • General Ill Feeling
    • Sudden Numbness or Weakness, Especially on One Side of The Body
    • Sudden Headache, Confusion, Problems with Vision, Speech, or Balance
    • Feeling Light-Headed, Fainting
    • Confusion, Weakness, Lack of Coordination
    • Nausea, Stomach Pain, Low Fever, Loss of Appetite
    • Dark Urine, Clay-Colored Stools, Jaundice (yellowing of the skin or eyes)
    • Seizure (convulsions)
    • Unusual Thoughts or Behavior, Hallucinations (seeing things)
    • Easy Bruising or Bleeding, Unusual Weakness

    Continue using Flexeril and talk with your doctor if you have any of these less serious side effects:

    • Dry Mouth, Increased Thirst
    • Blurred Vision
    • Drowsiness, Dizziness, Tired Feeling
    • Feeling Nervous or Irritable
    • Heartburn, Loss of Appetite, Stomach Pain, Nausea, Vomiting
    • Muscle Weakness
    • Diarrhea, Constipation, Gas
    • Sore Throat, Cold Symptoms

    Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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    Drug Interactions

    Before taking Flexeril, tell your doctor if you are using any drugs that make you sleepy such as:

    • alcohol
    • cold medicine
    • pain medication
    • muscle relaxers
    • medicine for seizures, depression or anxiety

    Medications that can increase drowsiness caused by Flexeril include:

    • amitriptyline (Elavil®)
    • citalopram (Celexa®)
    • clomipramine (Anafranil®)
    • desipramine (Norpramin®)
    • escitalopram (Lexapro®)
    • fluoxetine (Prozac®, Sarafem®)
    • fluvoxamine (Luvox®)
    • imipramine (Tofranil®)
    • nortriptyline (Pamelor®)
    • paroxetine (Paxil®)
    • sertraline (Zoloft®)
    • meperidine (Demerol®)
    • morphine (MS Contin, MSIR®)
    • propoxyphene (Darvon®, Darvocet®)
    • hydrocodone (Lorcet®, Vicodin®)
    • oxycodone (Percocet®, Percodan®)
    • fentanyl (Duragesic®)
    • codeine (Tylenol #3®)
    • prescription cough medicines
    • phenobarbital (Solfoton®, Luminal®)
    • amobarbital (Amytal®)
    • secobarbital (Seconal®)
    • chlorpromazine (Thorazine®)
    • fluphenazine (Prolixin®)
    • mesoridazine (Serentil®)
    • perphenazine (Trilafon®)
    • prochlorperazine (Compazine®)
    • thioridazine (Mellaril®)
    • trifluoperazine (Stelazine®)
    • diazepam (Valium®)
    • alprazolam (Xanax®)
    • lorazepam (Ativan®)
    • clorazepate (Tranxene®)

    If you are using any of these drugs, you may not be able to use Flexeril, or you may need dosage adjustments or special tests during treatment.

    There may be other drugs not listed that can affect Flexeril. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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