Drug Database - Gabapentin
New research supported by the National Institutes of Health's National Institute of
Arthritis and Musculoskeletal and Skin Diseases (NIAMS) shows that the
anticonvulsant medication gabapentin, which is used for certain types of seizures, can
be an effective treatment for the pain and other symptoms associated with the common,
often hard-to-treat chronic pain disorder, Fibromyalgia (FM).
In the NIAMS-sponsored, randomized, double-blind clinical trial of 150 women (90 percent)
and men with the condition, Lesley M. Arnold, M.D., director of the Women's Health
Research Program at the University of Cincinnati College of Medicine, and her colleagues
found that those taking gabapentin at dosages of 1,200 to 2,400 mg daily for 12
weeks displayed significantly less pain than those taking placebo. Patients taking
gabapentin also reported significantly better sleep and less fatigue. For the majority
of participants, the drug was well tolerated. The most common side effects included
dizziness and sedation, which were mild to moderate in severity in most cases.