FM/CFS/ME RESOURCES - Drug Database - Lodine


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Drug Database - Lodine Lodine 300 mg. capsule

Generic Name: etodolac (ee-toe-DOE-lak)

Brand Names: Lodine®, LodineXL®

Classification: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Issue Date: 1985

Lodine is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Lodine works by reducing hormones that cause inflammation and pain in the body. Lodine is used to treat pain or inflammation caused by arthritis, FM, CFS, ME. Lodine may also be used for purposes other than those listed here.

  • How To Use This Medicine
  • Discuss With Your Doctor
  • If You Miss A Dose
  • In Case of Overdose
  • What To Avoid
  • Side Effects
  • Drug Interactions
  • Divider
    How To Use This Medicine

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

    Do not crush, chew, or break an extended-release tablet. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking the pill would cause too much of the drug to be released at one time.

    It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve.

    If you take Lodine for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

    This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Lodine.

    Store Lodine at room temperature away from moisture and heat.

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    Discuss With Your Doctor

    Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

    NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

    Do not use this medication if you are allergic to Lodine, or if you have a history of allergic reaction to aspirin or other NSAIDs.

    Before taking Lodine, tell your doctor if you are allergic to any drugs, or if you have:

    • History of heart attack, stroke, or blood clot
    • Heart disease, congestive heart failure, high blood pressure
    • History of stomach ulcers or bleeding
    • Liver or kidney disease
    • Asthma
    • Polyps in your nose
    • Bleeding or blood clotting disorder
    • If you smoke

    If you have any of these conditions, you may not be able to use Lodine, or you may need a dosage adjustment or special tests during treatment.

    This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking Lodine during the last 3 months of pregnancy may result in birth defects. Do not take Lodine during pregnancy unless your doctor has told you to. It is not known whether Lodine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Do not give this medicine to a child younger than 6 years old without the advice of a doctor.

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    If You Miss A Dose

    Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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    In Case of Overdose

    Seek emergency medical attention if an overdose is suspected.

    Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Lodine overdose may include:

    • Nausea
    • Vomiting
    • Stomach pain
    • Drowsiness
    • Black or bloody stools
    • Coughing up blood
    • Shallow breathing
    • Fainting
    • Coma

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    What To Avoid

    Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Lodine (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains:

    • aspirin
    • ibuprofen
    • ketoprofen
    • naproxen

    Do not drink alcohol while taking Lodine. Alcohol can increase the risk of stomach bleeding caused by Lodine.

    Avoid prolonged exposure to sunlight. Lodine may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

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    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • Hives
    • Difficulty breathing
    • Swelling of your face, lips, tongue, or throat

    STOP taking Lodine and SEEK MEDICAL ATTENTION or call your doctor AT ONCE if you have any of these SERIOUS side effects:

    • Chest pain, weakness, shortness of breath
    • Slurred speech, problems with vision or balance
    • Black, bloody, or tarry stools
    • Coughing up blood or vomit that looks like coffee grounds
    • Swelling or rapid weight gain
    • Urinating less than usual or not at all
    • Nausea, stomach pain
    • Low fever
    • Loss of appetite
    • Dark urine, clay-colored stools
    • Jaundice (yellowing of the skin or eyes)
    • Fever, sore throat, and headache with a severe blistering, peeling, and red skin rash
    • Bruising, severe tingling, numbness, pain, muscle weakness
    • Headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin
    • Seizure (convulsions)

    Keep taking Lodine and talk to your doctor if you have any of these less serious side effects:

    • Upset stomach, mild heartburn or stomach pain
    • diarrhea, constipation
    • Bloating, gas
    • Dizziness, headache
    • Nervousness
    • Skin itching or rash
    • Sore throat, stuffy nose
    • Blurred vision
    • Ringing in your ears

    Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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    Drug Interactions

    Before taking Lodine, tell your doctor if you are taking any of the following drugs:

    • warfarin (Coumadin®)
    • lithium (Eskalith, Lithobid®)
    • methotrexate (Rheumatrex®, Trexall®)
    • steroids (prednisone and others)
    • aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs)
    • diclofenac (Cataflam®, Voltaren®)
    • flurbiprofen (Ansaid®)
    • indomethacin (Indocin®)
    • ketoprofen (Orudis®)
    • ketorolac (Toradol®)
    • mefenamic acid (Ponstel®)
    • meloxicam (Mobic®)
    • nabumetone (Relafen®)
    • naproxen (Aleve®, Naprosyn®)
    • piroxicam (Feldene®)
    • benazepril (Lotensin®)
    • captopril (Capoten®)
    • fosinopril (Monopril®)
    • enalapril (Vasotec®)
    • lisinopril (Prinivil®, Zestril®)
    • ramipril (Altace®)

    If you are using any of these drugs, you may not be able to use Lodine or you may need dosage adjustments or special tests during treatment.

    There may be other drugs not listed that can affect Lodine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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