Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed
against the good it will do. This is a decision you and your doctor will make. For
moclobemide, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to
moclobemide or monoamine oxidase inhibitors. Also tell your doctor and pharmacist
if you are allergic to any other substances, such as foods, preservatives, or dyes.
Studies of moclobemide use in pregnant women have not been done. In some animal
studies, weight gain was decreased in pregnant females or their offspring after
high doses of moclobemide. Before taking this medicine, make sure your doctor
knows if you are pregnant or if you may become pregnant.
Small quantities of moclobemide pass into the breast milk. Moclobemide is not
recommended during breast-feeding, because it may cause unwanted effects in nursing babies.
Studies on moclobemide have been done only in adult patients, and there is no
specific information comparing use of moclobemide in children with use in other age groups.
Older adults are especially
sensitive to the effects of moclobemide. This may increase the chance of side
effects during treatment. Dizziness or lightheadedness may be especially likely to
occur in elderly patients, who are usually more sensitive than younger adults to
Although certain medicines should not be used together at all, in other cases two
different medicines may be used together even if an interaction might occur. In these
cases, your doctor may want to change the dose, or other precautions may be necessary.
When you are taking moclobemide, it is especially important that your doctor and
pharmacist know if you are taking any of the following:
- Appetite suppressants (diet pills)
- Medicine for asthma or other breathing problems
- Medicines for colds, sinus problems, or hay fever - including nose drops, sprays)
- Meperidine (Demerol®)
- fluvoxamine (Luvox®)
- fluoxetine (Prozac®)
- paroxetine (Paxil®)
- sertraline (Zoloft®)
- amitriptyline (Elavil®)
- amoxapine (Asendin®)
- clomipramine (Anafranil®)
- desipramine (Norpramin®)
- doxepin (Sinequan®)
- imipramine (Tofranil®)
- nortriptyline (Aventyl®)
- protriptyline (Vivactil®)
- trimipramine (Surmontil®)
Using these medicines together may increase the chance of serious side effects.
Cimetidine (Tagamet®), may increase the effect of moclobemide; moclobemide
doses may need to be lowered by approximately 50% in patients using cimetidine.
Use of Monoamine oxidase (MAO) inhibitors such as:
- isocarboxazid (Marplan®)
- phenelzine (Nardil®)
- procarbazine (Matulane®)
- selegiline (Eldepryl®)
Should be stopped within 2 weeks of taking monoamine oxidase (MAO) inhibitors.
They may cause very serious side effects, such as sudden high body temperature,
extremely high blood pressure, and severe convulsions; at least 14 days should be
allowed between stopping treatment with one medicine and starting treatment with the