Drug Database - NADH
Nicotinamide Adenine Dinucleotide
Enzyme / Dietary Supplement
NADH is the abbreviation used for Nicotinamide Adenine Dinucleotide, one of the most
important coenzymes in the human brain and body.
A coenzyme is the active, or working form of a vitamin. NADH is the reduced (electron-
energy rich) coenzyme form of vitamin B3, while NAD is the oxidized (burned) coenzyme form
NAD and NADH are converted into each other in numerous different metabolic activities. In
some metabolic reactions it is NAD which is the needed catalyst, with NADH a useful
by-product, in other reactions the situation is reversed.
NAD and NADH also serve to activate various enzymes, NAD for example, activates alcohol
dehydrogenase and acetaldehyde dehydrogenase that are the two enzymes needed to detoxify
the alcohol we drink into carbon dioxide and water.
NADH is the first of five enzyme complexes of the electron transport chain, where much of
the ATP bioenergy that runs every biological process of our lives is formed.