Precautions While on this Medicine
While you are taking nefazodone you may need to be monitored for worsening symptoms
of depression and/or suicidal thoughts at the start of therapy or when doses are changed.
This concern about the increased risk of suicidal thoughts or behaviors may be greater if
you are 18 years of age or younger and are taking nefazodone. In patients younger
than 18 years, the period of risk may extend beyond start of therapy or when doses are
changed. Your doctor may want you to monitor for the following symptoms:
- panic attacks
- difficulty sleeping
- severe restlessness
- mania (mental and/ or physical hyperactivity)
These symptoms may be associated with the development of worsening symptoms of
depression and/or suicidal thoughts or actions. Contact your healthcare provider if
you develop any new or worsening mental health symptoms during treatment with
nefazodone. Do not stop taking nefazodone.
In RARE cases, treatment with nefazodone has been associated with serious liver
problems, sometimes resulting in liver transplant or death.
Contact your doctor
IMMEDIATELY if you experience:
- yellowing of the skin or eyes
- unusually dark urine
- loss of appetite that lasts several days or longer
- severe nausea
- stomach pain
These may be early signs of liver problems.
Do not take nefazodone if you are taking any of the following drugs:
- isocarboxazid (Marplan®)
- phenelzine (Nardil®)
- tranylcypromine (Parnate®)
- cisapride (Propulsid®)
- pimozide (Orap®)
- triazolam (Halcion®)
- carbamazepine (Tegretol®, TegretolXR®, Epitol®, Carbatrol®)
These drugs can cause very serious interactions with nefazodone that could lead
to seizures, heart damage, and even death. Before taking this medication, tell your
doctor if you have:
- heart disease
- high or low blood pressure
- irregular heartbeats
- manic episodes (extreme agitation or excitability)
- kidney disease
- liver disease
You may not be able to take nefazodone, or you may require a dosage adjustment or
special monitoring during treatment if you have any of the conditions listed above.
It is not known whether nefazodone will harm an unborn baby. Do not take nefazodone
without first talking to your doctor if you are pregnant or could become pregnant
during treatment. It is not known whether nefazodone passes into breast milk. Do
not take nefazodone without first talking to your doctor if you are breast-feeding.
If you are over 60 years of age, you may be more likely to experience side effects