FM/CFS/ME RESOURCES - Drug Database - Norpramin

 

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Drug Database - Norpramin Norpramin 10 mg. tablet

Generic Name: desipramine (des-IP-ra-meen)

Brand Names: Norpramin®

Classification: Tricyclic Antidepressant

Issue Date: October 31, 1999

Norpramin is a tricyclic antidepressant. Norpramin affects chemicals in the brain that may become unbalanced. Norpramin is used to treat symptoms of depression.

  • Before Using This Medicine
  • How To Use This Medicine
  • Precautions While on this Medicine
  • Side Effects
  • Overdosage
  • Drug Interactions
  • Divider
    Before Using This Medicine

    Do not use this medication if you have recently had a heart attack, or if you have used an MAO inhibitor such as:

    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    within the past 14 days.

    You may have suicidal thoughts or behavior when you start taking an antidepressant, especially if you are under 18 years old. You will need to be monitored for worsening symptoms of depression or suicidal thoughts. Your doctor should check you at regular visits during the first 12 weeks of treatment, or whenever your dose is changed.

    Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/ or physical hyperactivity)
    • thoughts of suicide or hurting yourself

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    How To Use This Medicine

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.

    If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Norpramin. You may need to stop using the medicine for a short time.

    Do not stop using Norpramin without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping this medication suddenly could cause you to have unpleasant side effects.

    It may take a few weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment.

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    Precautions While on this Medicine

    Do not use this medication if you are allergic to Norpramin, or if you have recently had a heart attack.

    Do not use Norpramin if you have used an MAO inhibitor such as:

    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    within the past 14 days. Serious, life-threatening side effects can occur if you take Norpramin before the MAO inhibitor has cleared from your body.

    Before taking Norpramin, tell your doctor if you are allergic to any drugs, or if you have:

    • heart disease
    • history of heart attack, stroke, or seizures
    • bipolar disorder (manic-depression)
    • schizophrenia or other mental illness
    • liver disease
    • overactive thyroid
    • diabetes (Norpramin may raise or lower blood sugar)
    • glaucoma
    • problems with urination

    If you have any of these conditions, you may not be able to use Norpramin, or you may need a dosage adjustment or special tests during treatment.

    You may have suicidal thoughts or behavior when you first start taking an antidepressant, especially if you are under 18 years old. Watch for worsening symptoms of depression or suicidal thoughts. Your doctor should check you at regular visits during the first 12 weeks of treatment, or whenever your dose is changed.

    In addition to you watching for changes in your own symptoms, your family or caregivers should be alert to changes in your mood or symptoms.

    Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/ or physical hyperactivity)
    • thoughts of suicide or hurting yourself

    This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

    It is not known whether Norpramin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

    Older adults may be more likely to have side effects from this medication.

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    Overdosage

    Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Norpramin can be fatal.

    Symptoms of a Norpramin overdose include:

    • extreme drowsiness
    • vomiting
    • blurred vision
    • confusion
    • hallucinations
    • muscle stiffness
    • feeling hot or cold
    • seizure (convulsions)
    • coma

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    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • hives
    • difficulty breathing
    • swelling of your face, lips, tongue, or throat

    Call your doctor at once if you have any of these serious side effects:

    • fast, pounding, or uneven heart rate
    • chest pain or heavy feeling
    • pain spreading to the arm or shoulder
    • nausea, sweating, general ill feeling
    • sudden numbness or weakness, especially on one side of the body
    • sudden headache, confusion, problems with vision, speech, or balance
    • confusion, hallucinations, or seizure (convulsions)
    • easy bruising or bleeding, unusual weakness
    • feeling light-headed, fainting
    • tremors, restless muscle movements in your eyes, tongue, jaw, or neck
    • fever with confusion, muscle stiffness, sweating, and fast or uneven heartbeats
    • urinating more or less than usual
    • extreme thirst with headache, nausea, vomiting, and weakness
    • skin rash, bruising, severe tingling, numbness, pain, and muscle weakness
    • nausea, stomach pain, low fever, loss of appetite
    • dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

    Less serious side effects may be more likely to occur, such as:

    • vomiting, constipation
    • dry mouth, unpleasant taste
    • weakness, lack of coordination
    • feeling anxious, restless, dizzy, or drowsy
    • sleep problems (insomnia), nightmares
    • blurred vision
    • trouble concentrating
    • headache
    • ringing in your ears
    • breast swelling (in men or women)
    • decreased sex drive, impotence, or difficulty having an orgasm
    • drowsiness, tiredness
    • amnesia or forgetfulness
    • dizziness
    • blurred vision
    • feeling nervous or irritable
    • sleep problems (insomnia)
    • muscle weakness, lack of balance or coordination
    • skin rash
    • dry mouth
    • headache

    Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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    Drug Interactions

    Before taking Norpramin, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as:

    • citalopram (Celexa®)
    • escitalopram (Lexapro®)
    • fluoxetine (Prozac®, Sarafem®)
    • fluvoxamine (Luvox®)
    • paroxetine (Paxil®)
    • sertraline (Zoloft®)

    Before taking Norpramin, tell your doctor if you are currently using any of the following drugs:

    • cimetidine (Tagamet®)
    • guanethidine (Ismelin®)
    • flecainide (Tambocor®)
    • propafenone (Rhythmol®)
    • quinidine (Cardioquin®, Quinidex®, Quinaglute®)

    If you are using any of these drugs, you may not be able to use Norpramin, or you may need dosage adjustments or special tests during treatment.

    There are many other medicines that can interact with Norpramin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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