FM/CFS/ME RESOURCES - Drug Database - Propoxyphene

 

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Drug Database - Propoxyphene Propoxyphene 650 mg. tablet

Generic Name: propoxyphene (pro-POX-i-feen)

Brand Names: Darvon®, Darvon-N®, PP-Cap®

Classification: Narcotic Pain Reliever

Issue Date: 1977

Propoxyphene is in a class of drugs called narcotic analgesics. It is used to treat moderate-to-severe pain.

  • Before Using This Medicine
  • How To Use This Medicine
  • Precautions While on this Medicine
  • Side Effects
  • If You Miss A Dose
  • Drug Interactions
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    Before Using This Medicine

    Do not stop taking propoxyphene suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you very uncomfortable. Your doctor may want to gradually reduce your dose. Do not take propoxyphene if you suffer from depression or have suicidal thoughts.

    Propoxyphene will cause drowsiness and fatigue. Avoid alcohol, sleeping pills, antihistamines, sedatives, and tranquilizers except under the supervision of your doctor. These may also make you drowsy.

    Propoxyphene will also cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet can also help to alleviate constipation.

    Never take more propoxyphene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

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    How To Use This Medicine

    Take propoxyphene exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

    Take each dose with a full glass of water. Take propoxyphene with food or milk if it upsets your stomach.

    Never take more of this medication than is prescribed for you. Too much propoxyphene could be very harmful. The maximum amount of propoxyphene that can be taken safely in one day is 390 mg (6 Darvon capsules). Do not exceed this amount.

    Do not stop taking propoxyphene suddenly if you have been taking it continuously for more than 5 to 7 days. Stopping suddenly could cause withdrawal symptoms and make you feel uncomfortable. Your doctor may want to gradually reduce your dose.

    Increase the amount of fiber and water (six to eight full glasses daily) in your diet to prevent constipation.

    Do not share this medication with anyone else. Store propoxyphene at room temperature away from moisture and heat.

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    Precautions While on this Medicine

    Propoxyphene is habit forming and should only be used under close supervision if you have an alcohol or drug addiction. Propoxyphene should not be taken if you suffer from depression or have suicidal thoughts.

    Before taking this medication, tell your doctor if you have:

    • kidney disease
    • liver disease
    • asthma
    • urinary retention
    • enlarged prostate
    • hypothyroidism
    • seizures or epilepsy
    • gallbladder disease
    • head injury
    • Addisons disease

    You may not be able to take propoxyphene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

    Propoxyphene may cause addiction and withdrawal symptoms as well as other harmful effects in an unborn baby. Do not take propoxyphene without first talking to your doctor if you are pregnant. Propoxyphene may also cause addiction and withdrawal symptoms in a nursing baby. Do not take propoxyphene without first talking to your doctor if you are breast-feeding a baby. Children younger than 12 years of age should not take propoxyphene. If you are older than 60 years you may be more likely to experience side effects from propoxyphene therapy. Use extra caution.

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    If You Miss A Dose

    Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

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    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • skin rash or hives
    • difficulty breathing
    • swelling of your face, lips, tongue, or throat

    Call your doctor at once if you have any of these serious side effects:

    • slow, weak breathing
    • seizures
    • cold, clammy skin
    • severe weakness
    • dizziness
    • unconsciousness

    Other, less serious side effects may be more likely to occur. Continue to take Propoxyphene and talk to your doctor if you experience:

    • constipation
    • dry mouth, nausea, vomiting
    • decreased appetite
    • dizziness, tiredness, or lightheadedness
    • muscle twitches
    • sweating
    • itching
    • decreased urination
    • decreased sex drive

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    Drug Interactions

    Do not take Propoxyphene if you have taken a monoamine oxidase inhibitor (MAOI) such as:

    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • tranylcypromine (Parnate®)

    in the last 14 days. Dangerous side effects could result.

    The most serious interactions affecting Propoxyphene are with those drugs that also cause sedation. The following drugs may lead to dangerous sedation if taken with codeine:

    • brompheniramine (Dimetane®, Bromfed®, others)
    • diphenhydramine (Benadryl®, Nytol®, Compoz®, others)
    • chlorpheniramine (Chlor-Trimeton®, Teldrin®, others)
    • amitriptyline (Elavil®)
    • doxepin (Sinequan®)
    • fluoxetine (Prozac®)
    • sertraline (Zoloft®)
    • paroxetine (Paxil®)
    • amoxapine (Asendin®)
    • clomipramine (Anafranil®)
    • desipramine (Norpramin®)
    • imipramine (Tofranil®)
    • nortriptyline (Pamelor®)
    • protriptyline (Vivactil®)
    • belladonna (Donnatal®)
    • clidinium (Quarzan®)
    • dicyclomine (Bentyl®, Antispas®)
    • hyoscyamine (Levsin®, Anaspaz®)
    • ipratropium (Atrovent®)
    • propantheline (Pro-Banthine®)
    • scopolamine (Transderm-Scop®)
    • chlorpromazine (Thorazine®)
    • fluphenazine (Prolixin®)
    • thioridazine (Mellaril®)
    • prochlorperazine (Compazine®)
    • phenobarbital (Solfoton®, Luminal®)
    • amobarbital (Amytal®)
    • secobarbital (Seconal®)
    • alprazolam (Xanax®)
    • diazepam (Valium®)
    • lorazepam (Ativan®)
    • flurazepam (Dalmane®)
    • temazepam (Restoril®)

    Do not take any of the drugs listed above without the approval of your doctor.

    Drugs other than those listed here may also interact with Propoxyphene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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