Drug Database - Risperidone
Risperidone is an antipsychotic medication. It works by changing the effects of chemicals
in the brain. Risperidone is used to treat schizophrenia and symptoms of bipolar
disorder (manic depression). It is also used in autistic children to treat symptoms of
irritability. Risperidone may also be used for purposes other than those listed in this
Risperidone is not for use in psychotic conditions related to dementia. This medication
may cause heart failure, sudden death, or pneumonia in older adults with dementia-related
Do not give Risperidone to a child without a doctor's advice.
While you are taking risperidone, you may be more sensitive to temperature extremes
such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or
dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is
easier to become dangerously overheated and dehydrated while you are taking this
Risperidone may impair your thinking or reactions. Be careful if you drive or do anything
that requires you to be alert. Drinking alcohol can increase certain side effects of
Stop using risperidone and call your doctor at once if you have fever, stiff muscles,
confusion, sweating, fast or uneven heartbeats, restless muscle movements in your face or
neck, tremor (uncontrolled shaking), trouble swallowing, feeling light-headed, or fainting.
There may be other drugs that can interact with risperidone. Tell your doctor about all
medications you use. This includes prescription, over-the-counter, vitamin, and herbal
products. Do not start a new medication without telling your doctor.
How To Take Risperidone
Take risperidone exactly as prescribed by your doctor. Do not take in larger or smaller
amounts or for longer than recommended. Follow the directions on your prescription
Risperidone can be taken with or without food.
To take risperidone orally disintegrating tablets (Risperdal M-Tabs):
Keep the tablet in its blister pack until you are ready to take the medicine. Open the
package and peel back the foil from the tablet blister. Do not push a tablet through the
foil or you may damage the tablet.
Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve
Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Swallow several times as the tablet dissolves. If desired, you may drink liquid after the
tablet is completely dissolved.
It is important to take risperidone regularly to get the most benefit. Get your
prescription refilled before you run out of medicine completely.
Measure the liquid form of risperidone with a special dose-measuring spoon or cup, not a
regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for
Do not mix the liquid form of risperidone with cola or tea.
It may take several weeks of using this medicine before your symptoms improve. For best
results, keep using the medication as directed. Talk with your doctor if your symptoms do
Store risperidone at room temperature away from moisture, light, and heat. Do not allow
the liquid form of risperidone to freeze.
If You Forget A Dose
Take the missed dose as soon as you remember. Skip the missed dose if it is almost
time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
In Case of Overdose
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local
poison control center
http://www.aapcc.org/findyour.htm), or emergency room IMMEDIATELY.
Symptoms may include:
- fast heart rate
- feeling light-headed
- restless muscle movements in your eyes, tongue, jaw, or neck
Risperidone is not for use in psychotic conditions related to dementia. Risperidone may
cause heart failure, sudden death, or pneumonia in older adults with dementia-related
conditions. You should not use this medication if you are allergic to risperidone.
You should not use this medication if you are allergic to risperidone.
To make sure you can safely take risperidone, tell your doctor if you have any of these
- liver disease
- kidney disease
- heart disease, high blood pressure, heart rhythm problems
- a history of heart attack or stroke
- a history of low white blood cell (WBC) counts
- a history of breast cancer
- seizures or epilepsy
- diabetes (risperidone may raise your blood sugar)
- a history of suicidal thoughts
- Parkinson's disease
- trouble swallowing
The risperidone orally disintegrating tablet may contain phenylalanine. Talk to your
doctor before using this form of risperidone if you have phenylketonuria (PKU).
Risperidone may cause you to have high blood sugar (hyperglycemia). Talk to your doctor
if you have any signs of hyperglycemia such as increased thirst or urination, excessive
hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis
while you are taking risperidone.
Atypical antipsychotic drugs have been associated with metabolic changes that may increase
cardiovascular/cerebrovascular risk. While all of the drugs in the class have been shown
to produce some metabolic changes, each drug has its own specific risk profile.
Weight gain has been observed with atypical antipsychotic use. Clinical monitoring of
weight is recommended.
FDA pregnancy category C. It is not known whether risperidone will harm an unborn baby.
Tell your doctor if you are pregnant or plan to become pregnant while using this
medication. It is not known whether risperidone passes into breast milk or if it could
harm a nursing baby. Do not use this medication without telling your doctor if you are
breast-feeding a baby.
Get emergency medical help if you have any of these signs of an allergic reaction:
- difficulty breathing
- swelling of your face
Seek medical attention right away if any of these SEVERE side effects occur:
- fever, stiff muscles, confusion, sweating, fast or uneven heartbeats
- restless muscle movements in your eyes, tongue, jaw, or neck
- tremor (uncontrolled shaking)
- fever, chills, body aches, flu symptoms
- white patches or sores inside your mouth or on your lips
- trouble swallowing; or
- feeling light-headed, fainting
Check with your doctor if any of these most COMMON side effects persist or become
- mild restlessness, drowsiness, or tremor
- sleepiness, dreaming more than usual
- blurred vision
- dizziness or headache
- weight gain
- problems with urination
- nausea, dry mouth, constipation; or
- decreased sex drive, impotence, or difficulty having an orgasm
This is not a complete list of side effects and others may occur. Call your doctor for
medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Commonly-Observed Adverse Reactions in Double-Blind, Placebo- Controlled Clinical Trials -
In another study with patients treated for irritability associated with autistic disorder,
headache (6%), epistaxis (6%) and pyrexia (6%) were also observed in Risperdal-treated
Other Adverse Reactions Observed During the Clinical Trial Evaluation of Risperidone
- Blood and Lymphatic System Disorders: neutropenia
- Nervous System Disorders: head titubation
- blood cholesterol increased, blood triglycerides increased
- drug withdrawal syndrome neonatal, dysgeusia
Before you take risperidone, tell your doctor if you regularly use other medicines
that make you sleepy (such as cold or allergy medicine, narcotic pain medicine,
sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety).
They can add to sleepiness caused by risperidone.
Also tell your doctor if you are taking any of the following medicines:
- carbamazepine (Carbatrol, Tegretol)
- phenytoin (Dilantin)
- phenobarbital (Luminal, Solfoton)
- clozapine (Clozaril)
- fluoxetine (Prozac) or paroxetine (Paxil)
- rifampin (Rifadin, Rimactane, Rifater)
- medicines used to treat Parkinson's Disease such as:
- levodopa (Dopar, Larodopa, Sinemet, Atamet, others)
- bromocriptine (Parlodel, others)
- pergolide (Permax)
- pramipexole (Mirapex)
- ropinirole (Requip)