How To Use This Medicine
Xyrem is habit-forming and you can become physically and psychologically
dependent on it. Xyrem should be used exactly as your doctor has prescribed
it for you. Do not use more of the medication than recommended. Do not take Xyrem
for longer than your doctor has prescribed. Talk with your doctor if you feel that
the medication is not working.
This medication comes with patient instructions for safe and effective use. Follow
these directions carefully. Do not allow anyone else to use your medication.
Take Xyrem on an empty stomach several hours after a meal. It is important to
take Xyrem at the same time each night.
Xyrem must be taken at bedtime and again two and a half to four hours later.
This medicine works very fast and should be taken while you are sitting in bed ready
for sleep. Prepare both doses while you are getting ready for bed, so that you will not
have to get up to prepare the second dose. Place the second dose next to your bed so you
can take it without getting up. You will most likely need to set an alarm to awaken for
the second dose.
Each dose of Xyrem must be mixed with two ounces (one quarter cup) of water in
the child-resistant dosing cups provided with the medication. Both doses must be used
within the same night. Throw away any Xyrem dose that has been mixed with water
but not used within 24 hours of mixing.
You may need to be on a low-salt diet while you are using Xyrem, especially if
you have high blood pressure, kidney disease, or heart disease.
Xyrem is also known as GHB, a known street drug of abuse. Because of the
potential for abuse and the serious side effects that may occur, Xyrem
is available only through a special program. Your doctor will explain the risks and
benefits of using Xyrem, and the medication will be delivered to you from a
To be sure this medication is helping your condition, your doctor will need to see you
on a regular basis. It is important that you not miss any scheduled visits to your doctor.
Do not stop using Xyrem suddenly or you may have withdrawal effects.
Your doctor may recommend a gradual reduction in dose.