FM/CFS/ME RESOURCES - Drug Database - Zoloft

 

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Drug Database - Zoloft Zoloft 50 mg. tablet

Generic Name: sertraline (SER-tra-leen)

Brand Names: Zoloft®

Classification: Antidepressant - Selective Serotonin Reuptake Inhibitors (SSRIs)

Issue Date: 2002

Zoloft is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Zoloft affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms.

Zoloft is used to treat depression, obsessive-compulsive disorder, panic disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

  • Before Using This Medicine
  • How To Use This Medicine
  • Precautions While on this Medicine
  • Side Effects
  • Overdosage
  • Drug Interactions
  • Divider
    Before Using This Medicine

    You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. Talk with your doctor about this risk. While you are taking Zoloft you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. In addition to you watching for changes in your own symptoms, your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

    Contact your doctor promptly if you have any of the following side effects especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/ or physical hyperactivity)
    • thoughts of suicide or hurting yourself

    Do not take Zoloft together with:

    • pimozide (Orap®)
    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    You must wait at least 14 days after stopping an MAOI before you can take Zoloft. After you stop taking Zoloft, you must wait at least 14 days before you start taking an MAOI.

    SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Zoloft, do not stop taking the medication without first talking to your doctor.

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    How To Use This Medicine

    Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication.

    Take each tablet with water. Zoloft may be taken with or without food. Try to take the medicine at the same time each day. Follow the directions on your prescription label.

    The oral liquid form of this medicine must be diluted before you take it. To be sure you get the correct dose, measure the liquid with medicine dropper provided, not with a regular table spoon. Mix the dose with 4 ounces (one-half cup) of water, ginger ale, lemon/lime soda, lemonade, or orange juice. Do not use any other liquids to dilute the medicine. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

    It may take 4 weeks or longer before you start feeling better. Do not stop using Zoloft without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly.

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    Precautions While on this Medicine

    You may have an increased risk of suicidal thoughts or behavior at the start of treatment with an antidepressant medication, especially if you are under 18 years old. Talk with your doctor about this risk. While you are taking Zoloft you will need to be monitored for worsening symptoms of depression and/or suicidal thoughts during the first weeks of treatment, or whenever your dose is changed. In addition to you watching for changes in your own symptoms, your family or other caregivers should be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks.

    Do not use Zoloft if you are using:

    • pimozide (Orap®)
    • isocarboxazid (Marplan®)
    • phenelzine (Nardil®)
    • rasagiline (Azilect®)
    • selegiline (Eldepryl®, Emsam®)
    • tranylcypromine (Parnate®)

    Serious and sometimes fatal reactions can occur when these medicines are taken with Zoloft. You must wait at least 14 days after stopping an MAO inhibitor before you can take Zoloft. After you stop taking Zoloft, you must wait at least 14 days before you start taking an MAOI.

    Before taking Zoloft, tell your doctor if you have:

    • liver
    • kidney disease
    • seizures
    • epilepsy
    • bipolar disorder (manic depression)
    • history of drug abuse or suicidal thoughts

    If you have any of these conditions, you may not be able to use Zoloft, or you may need a dosage adjustment or special tests.

    SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Zoloft, do not stop taking the medication without first talking to your doctor.

    It is not known whether Zoloft passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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    Overdosage

    Seek emergency medical attention if you think you have used too much of this medicine. A tramadol overdose can be fatal.

    Symptoms of a Zoloft overdose may include:

    • drowsiness
    • dizziness
    • nausea
    • vomiting
    • rapid heartbeat
    • agitation
    • tremor
    • confusion
    • seizures
    • coma

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    Side Effects

    Get emergency medical help if you have any of these signs of an allergic reaction:

    • hives
    • difficulty breathing
    • swelling of your face, lips, tongue, or throat

    Contact your doctor promptly if you have any of the following side effects, especially if they are new symptoms or if they get worse:

    • mood changes
    • anxiety
    • panic attacks
    • trouble sleeping
    • irritability
    • agitation
    • aggressiveness
    • severe restlessness
    • mania (mental and/ or physical hyperactivity)
    • thoughts of suicide or hurting yourself

    Call your doctor at once if you have any of these serious side effects:

    • seizure (convulsions)
    • tremors
    • shivering
    • muscle stiffness or twitching
    • problems with balance or coordination
    • agitation
    • confusion
    • sweating
    • fast heartbeat

    Other less serious side effects are more likely to occur, such as:

    • feeling nervous
    • restless, or unable to sit still
    • drowsiness, dizziness, weakness
    • sleep problems (insomnia)
    • nausea, diarrhea, dry mouth, or changes in appetite or weight
    • decreased sex drive, impotence, or difficulty having an orgasm

    Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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    Drug Interactions

    Talk to your doctor before taking any medicine for:

    • pain
    • arthritis
    • fever
    • swelling
    • aspirin
    • ibuprofen (Advil®, Motrin®)
    • naproxen (Aleve®, Naprosyn®)
    • diclofenac (Voltaren®)
    • indomethacin
    • piroxicam (Feldene®)
    • nabumetone (Relafen®)
    • etodolac (Lodine®)

    Taking any of these drugs with Zoloft may cause you to bruise or bleed easily.

    Before taking Zoloft, tell your doctor if you are using any of the following medicines:

    • tramadol (Ultram®, Ultram ER®, Ultracet®)
    • digitoxin (Crystodigin®)
    • phenytoin (Dilantin®)
    • valproate (Depacon®, Depakene®)
    • lithium (Lithobid®, Eskalith®)
    • warfarin (Coumadin®)
    • amitriptyline (Elavil®)
    • citalopram (Celexa®)
    • escitalopram (Lexapro®)
    • fluoxetine (Prozac®, Sarafem®)
    • fluvoxamine (Luvox®)
    • imipramine (Tofranil®)
    • nortriptyline (Pamelor®)
    • paroxetine (Paxil®)
    • almotriptan (Axert®)
    • frovatriptan (Frova®)
    • sumatriptan (Imitrex®)
    • naratriptan (Amerge®)
    • rizatriptan (Maxalt®)
    • zolmitriptan (Zomig®)
    • flecainide (Tambocor®)
    • propafenone (Rhythmol®)

    If you are using any of these drugs, you may not be able to use Zoloft, or you may need dosage adjustments or special tests during treatment.

    There may be other drugs not listed that can affect Zoloft. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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